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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1986 1
1988 1
1991 1
1999 3
2000 3
2001 1
2002 1
2003 1
2004 2
2005 2
2008 1
2009 3
2010 6
2011 1
2012 4
2013 4
2014 6
2015 5
2016 2
2017 8
2018 4
2019 5
2020 5
2021 12
2022 9
2023 6
2024 3

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91 results

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Page 1
Tofacitinib in juvenile idiopathic arthritis: a double-blind, placebo-controlled, withdrawal phase 3 randomised trial.
Ruperto N, Brunner HI, Synoverska O, Ting TV, Mendoza CA, Spindler A, Vyzhga Y, Marzan K, Grebenkina L, Tirosh I, Imundo L, Jerath R, Kingsbury DJ, Sozeri B, Vora SS, Prahalad S, Zholobova E, Butbul Aviel Y, Chasnyk V, Lerman M, Nanda K, Schmeling H, Tory H, Uziel Y, Viola DO, Posner HB, Kanik KS, Wouters A, Chang C, Zhang R, Lazariciu I, Hsu MA, Suehiro RM, Martini A, Lovell DJ; Paediatric Rheumatology International Trials Organisation (PRINTO) and Pediatric Rheumatology Collaborative Study Group (PRCSG). Ruperto N, et al. Lancet. 2021 Nov 27;398(10315):1984-1996. doi: 10.1016/S0140-6736(21)01255-1. Epub 2021 Nov 9. Lancet. 2021. PMID: 34767764 Clinical Trial.
Carnitine palmitoyltransferase deficiencies.
Bonnefont JP, Demaugre F, Prip-Buus C, Saudubray JM, Brivet M, Abadi N, Thuillier L. Bonnefont JP, et al. Mol Genet Metab. 1999 Dec;68(4):424-40. doi: 10.1006/mgme.1999.2938. Mol Genet Metab. 1999. PMID: 10607472 Review.
While CPT2 is a ubiquitous protein, two tissue-specific CPT1 isoforms-the so-called "liver" (L) and "muscle" (M) CPT1s-have been shown to exist. Amino acid and cDNA nucleotide sequences have been identified for all of these proteins. L-CPT1 deficiency (13 families reported …
While CPT2 is a ubiquitous protein, two tissue-specific CPT1 isoforms-the so-called "liver" (L) and "muscle" (M) CPT1s-have been show …
Treatment of Multisystem Inflammatory Syndrome in Children.
McArdle AJ, Vito O, Patel H, Seaby EG, Shah P, Wilson C, Broderick C, Nijman R, Tremoulet AH, Munblit D, Ulloa-Gutierrez R, Carter MJ, De T, Hoggart C, Whittaker E, Herberg JA, Kaforou M, Cunnington AJ, Levin M; BATS Consortium. McArdle AJ, et al. N Engl J Med. 2021 Jul 1;385(1):11-22. doi: 10.1056/NEJMoa2102968. Epub 2021 Jun 16. N Engl J Med. 2021. PMID: 34133854 Free PMC article.
Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer's disease.
Hafez DE, Dubiel M, La Spada G, Catto M, Reiner-Link D, Syu YT, Abdel-Halim M, Hwang TL, Stark H, Abadi AH. Hafez DE, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2175821. doi: 10.1080/14756366.2023.2175821. J Enzyme Inhib Med Chem. 2023. PMID: 36789662 Free PMC article.
The multitargeting potential of these H(3)R ligands towards AChE, BuChE and MAO-B enzymes was evaluated to yield compound 3s (pyrrolidin-1-yl-(6-((5-(pyrrolidin-1-yl)pentyl)oxy)benzo[d]thiazol-2-yl)methanone) as the most promising MTDL with a K(i) value of 0.036 muM at H(3)R and …
The multitargeting potential of these H(3)R ligands towards AChE, BuChE and MAO-B enzymes was evaluated to yield compound 3s (pyrrolidin-1-y …
Lupus in Latin-American patients: lessons from the GLADEL cohort.
Pons-Estel GJ, Catoggio LJ, Cardiel MH, Bonfa E, Caeiro F, Sato E, Massardo L, Molina-Restrepo JF, Toledano MG, Barile-Fabris LA, Amigo MC, Acevedo-Vásquez EM, Abadi I, Wojdyla D, Alarcón-Riquelme ME, Alarcón GS, Pons-Estel BA; GLADEL. Pons-Estel GJ, et al. Lupus. 2015 May;24(6):536-45. doi: 10.1177/0961203314567753. Epub 2015 Feb 18. Lupus. 2015. PMID: 25697768 Review.
Design, synthesis, and metabolite identification of Tamoxifen esterase-activatable prodrugs.
Elbagoury RM, Shenouda MA, Elnakib HE, Wober J, Abadi AH, Ahmed NS. Elbagoury RM, et al. Bioorg Chem. 2023 Feb;131:106303. doi: 10.1016/j.bioorg.2022.106303. Epub 2022 Nov 28. Bioorg Chem. 2023. PMID: 36455483
Compound 3d [E/Z Benzyl-carbamic acid4-{2-benzyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-but-1-enyl}-phenyl ester] showed GI(50) = 0.09 M on MCF-7 and GI(50) = 1.84 M on MDA-MB231 cell lines. To further validate our hypothesis, metabolites of selected novel analogue …
Compound 3d [E/Z Benzyl-carbamic acid4-{2-benzyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-but-1-enyl}-phenyl ester] showed GI(50) = 0.09 M …
Development of (4-Phenylamino)quinazoline Alkylthiourea Derivatives as Novel NF-κB Inhibitors.
Darwish SS, Chen PJ, Hamed MM, Wagdy RA, Chen SH, Abadi AH, Abdel-Halim M, Hwang TL, Engel M. Darwish SS, et al. Pharmaceuticals (Basel). 2022 Jun 22;15(7):778. doi: 10.3390/ph15070778. Pharmaceuticals (Basel). 2022. PMID: 35890077 Free PMC article.
One of the best compounds, 19, strongly inhibited the production of IL-6 (IC(50) = 0.84 M) and, less potently, of TNFalpha (IC(50) = 4.0 M); in comparison, the reference compound, caffeic acid phenethyl ester (CAPE), showed IC(50)s of 1.1 and 11.4 M, respecti …
One of the best compounds, 19, strongly inhibited the production of IL-6 (IC(50) = 0.84 M) and, less potently, of TNFalpha (IC(50) = …
91 results